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Seton Hall Pirates, Iowa State Cyclones among Giant Killer matchups to watch in NCAA tournament Midwest Region

Related Topics: Upset

It's upset time, baby. We've gone deep once again in analyzing each of the six Giant vs. Killer matchups for each of the four regions. Remember, a Giant Killer is any team that beats an opponent seeded at least five spots higher. See our full methodology for more details.

We are utilizing our standard categories of Best Bets, Worth A Long Look, Not Completely Crazy and Stay Away. If you object to a game's placement, you're arguing with math. Our statistical model generates upset odds for each game. Those odds are based on three key factors: basic power ratings, teams' "Secret Sauce" (their statistical similarity to past Davids and Goliaths) and the matchup between Giants and Killers' playing styles.