All you need to do is suspend everything you think you know, and just go with dumb luck.
March Madness is a time that is filled with multiple layers of enjoyment/agony. First is Selection Sunday. Second is filling out the bracket. Third is watching your bracket either succeed, or what happens more often, fall apart.
There are a lot of tips out there on how to craft the perfect bracket. Don't forget to pick those No. 12 seeds, because they tend to succeed. Never go against a No. 1 seed in the first round, because that has happened yet.