The Indianapolis Colts will host five non-divisional opponents at Lucas Oil Stadium as the AFC South is set to take on the AFC East and NFC North in 2024. Four of those five opponents made the playoffs last season, including the Buffalo Bills, Miami Dolphins, Pittsburgh Steelers and Detroit Lions.
- Buffalo Bills (11-6, first in AFC East)
It will be the Bills first trip to Indianapolis since 2018. Quarterback Josh Allen threw 29 touchdowns, tacked on another 15 rushing TDs and scored 90 points in 2023, which tied with Eagles’ QB Jalen Hurts for the most points scored among QBs.